Scientific program


Sunday 13th September 2015 – Cortile del Broletto, Piazza Vittoria, Pavia

18:30 Registration
19:30 Welcome cocktail

Monday 14th September 2015 – Sala degli Affreschi Almo Collegio Borromeo piazza Borromeo, 9 27100 Pavia, Italy

08:30 09:00 Registration
09:00 09:15 Welcome
I session Physics accelerators – Chairpersons: H.Tanaka, A.Makarov
09:15 09:45 H.Kumada Development status of a linac-based neutron source for BNCT in University of Tsukuba
09:45 10:05 S.Taskaev BNCT facility in BINP
10:05 10:25 I.Postuma Tailoring of an epithermal neutron beam for the RFQ-based facility of INFN
10:25 10:45 Y.Imahori Thin layer lithium target for the first hospital used of accelerator based BNCT
10:45 11:05 Coffee/tea break
II session
Physics, accelerators and other neutron sources – Chairpersons: S.Taskaev, I.Postuma
11:05 11:25 A.N. Makarov Studying of the Accompanying Current in the VITA facility
11:25 11:45 N.Protti Impact of variable RBE factor for fast neutrons in the design of BSAs for
BNCT facilities
11:45 12:05 V.Monti Hyperthermal Photo Neutron source based on medical Linac
12:05 12:25 M. Sztejnberg Fusion-based neutrons for BNCT: a discussion on current possibilities
12:25 12:45 M. Wielgosz The research and training station based on intelligent fission converter at the MARIA Reactor
12:45 13:45 lunch – Richini Garden – Almo Collegio Borromeo
III session Detectors – Chairpersons: I.Murata, M.Sztejnzberg
A.Tamaki Study of a New Neutron Spectrometer based on Liquid Moderator for BNCT – Experiment in a neutron field produced with an AmBe source and graphite moderator
14:05 14:25  S.Fatemi Preliminary results on the spectroscopy performance of a CdZnTe detector for boron imaging by Single Photon Emission Computed Tomography
14:25 14:45 K.Tyminska Filter/moderator system for a BNCT beam of epithermal neutrons at nuclear reactor Maria
14:45 15:05 M.Manabe  Feasibility study of BNCT-SPECT using GAGG scintillator
15:05 15:25 Coffee/tea break
IV session Detectors – Chairpersons: S.Altieri, M.A. Gadan
15:25 15:45 H.Hiramatsu Study of Gamma-Ray Dose Measurement in Neutron Field Using Radio-Photoluminescence Glass Dosimeter
15:45 16:05 Y. Ootani Experimental test of Neutron Intensity Monitor with Activation Foil for p-Li neutron source
16:05 16:25 M.Valero Advances in the beam design and development of the RA-3’s PGNAA facility for BNCT
16:25 16:45 K.Taki Development and Application of Real-time Neutron Monitor for BNCT
16:45 17:05  S.Nakamura Feasibility study of the measurement of gamma-ray dose and neutron fluences with a glass dosimeter in BNCT
17:05 V session Posters

Tuesday 15th September 2015 – Sala degli Affreschi Almo Collegio Borromeo piazza Borromeo, 9 27100 Pavia, Italy

I session Dosimetry – Chairpersons: H.Kumada, S.W.Kiger III
09:00 09:30 S.J. Gonzalez BNCT mixed field dosimetry, a new theoretical approach
09:30 09:50 M.Pedrosa Weighted kerma factors and the application of the LQ model for the estimation of the biological dose in BNCT
09:50 10:10 M.Golshanian Experimental and theoretical investigation on the use of TRR medical room for BNCT
10:10 10:30 M. Ferrari Gamma component dosimetry in the thermal column of the TRIGA reactor in PV
10:30 10:50 H.Koivunoro A comparison of the doses resulting from BNCT using the conventional RBE-weighted and the photon-isoeffective formalisms in patients with malignant glioma progressing after conventional radiotherapy
10:50 11:10 Coffee/tea break
II session Dosimetry – Chairpersons: Y.H.Liu, N.Protti
11:10 11:30 A. Khajeali Potential application of NIPAM polymer gel for dosimetric purposes in boron neutron capture therapy.
11:30 11:50 B. Smilgys Study of a methodology for in vitro dosimetry
11:50 12:10  E. Bavarnegin In-phantom BNCT dosimetry: The second step in TRR thermal BNCT program
12:10 12:30 R. Ramos Study of thermal scattering nuclear data for dosimetry calculations
12:30 13:30 lunch – Richini Garden – Almo Collegio Borromeo
III session Treatment Planning – Chairpersons: S.Gonzalez, H.Koivunoro
13:30 14:00 S.Kiger III Treatment Planning in BNCT
14:00 14:20 Y.Sakurai A study on improvement of dose distribution using bolus in BNCT for head and neck tumors
14:20 14:40 H.Tanaka Study on the extended collimator for Cyclotron-Based Epithermal Neutron  Source(C-BENS)
14:40 15:00 Yuan-Hao Liu A bi-tapered and air-gapped design of beam shaping assembly
15:00 15:20 Coffee/tea break
IV session Boron Imaging – Chairpersons: B. Smilgys, S. Bortolussi
15:20 15:40  L. Provenzano Extending neutron autoradiography and alpha spectrometry techniques for boron measurements in bone.
15:40 16:00 A.Kichigin A Method of controlled selective delivery of 10B into the brain tumour cells
16:00 16:20 K.Nakai Boron analysis and imaging by using micro particle induced gamma-ray emission (PIGE)
16:20 16:40 A.Portu Development of the autoradiography technique with UV-C sensitization for tissue sections
16:40 17:00 H.Michiue BSH peptide delivery system and drug pharmacokinetics by positron emission tomography (PET) imaging
17:00 V session Posters

Wednesday 16th September 2015 – Sala degli Affreschi Almo Collegio Borromeo piazza Borromeo, 9 27100 Pavia, Italy

I session Chemistry – Chairpersons: L.Panza, N.Dewi
09:00 09:30 L. Panza Development of boron compounds for BNCT: past and present
09:30 09:50 P.Boggio New Synthetic strategy of MRI/BNCT agents based on hydroboration reactions
09:50 10:10 D.Iffland Quantification of boron in biological samples for boron neutron capture therapy
10:10 10:30 A.Zaboronok Hyaluronic acid-melanin based boron-gold nanoparticles for combined neutron capture therapy and absorbed dose evaluation
10:30 10:50 M.Kellert Facile Synthesis of the Versatile Trifunctionalized Building Block 1,2-Bis(hydroxymethyl)-9-mercapto-1,2-dicarba-closo-dodecaborane(12)
10:50 11:10 Coffee/tea break
II session Chemistry/clinical issues – Chairpersons: D.Alberti, A.E. Schwint
11:10 11:30 T.Andoh Nanoparticulate p-Borono-L-phenylalanine formulations for BNCT: biodistribution study in tumour-bearing mice
11:30 11:50 N.Dewi Tumour growth suppression by gadolinium capture therapy with multiple inkections of Gd-DTPA-containing calcium phosphate-based nanoparticles
11:50 12:10 S.Miyatake Advantage and Disadvantage of Bevacizumab in BNCT
12:10 12:30 D. Ngoga Glioma heterogeneity as a means of patient stratification for BPA-based BNCT.
12:30 12:50 K.Igawa Boron Neutron Capture Therapy Clinical Pathway for Head and Neck Cancer
12:50 13:50 lunch – Richini Garden – Almo Collegio Borromeo
Clinical Workshop – BNCT and hadrontherapy: differences and common aspects Chairpersons: S.Rossi, A.Zonta
13:50 14:10 K.Ono Development of Accelerator Based BNCT and Relating Researches
14:10 14:30 S.Miyatake Merit and demerit of BNCT for the treatment of malignant brain tumors, in comparison with other particle radiation.
14:30 14:50 T.Yamamoto

Clinical trials for glioblastoma: BNCT and proton therapy in Tsukuba

14:50 15:10  L. Kankaanranta BNCT treatments for head and neck cancer patients; case studies
15:10 15:30 J. Lee Current development of BNCT in Taiwan and its future prospects
15:30 15:50 Coffee/tea break
Clinical Workshop – BNCT and hadrontherapy: differences and common aspectsChairpersons: T. Yamamoto, L. Kankaanranta
15:50 16:10 W.Sauerwein Dose in charged particle therapy and BNCT: Science and fiction
16:10 16:30 S.Molinello Planning study to compare NIRS and LEM approaches with a clinically-oriented strategies
16:30 16:50 F.Valvo Biological and clinical rationale for the use of high-LET particle in cancer therapy

Round table: How to integrate in clinical setting BNCT and CIRT (carbon ion RT)
Chairpersons: R.Orecchia, K.Ono

20:30 Social dinner at restaurant “Trattoria Ferrari” via dei Mille 111 – Pavia

 Thursday 17th September 2015 – Sala degli Affreschi Almo Collegio Borromeo piazza Borromeo, 9 27100 Pavia, Italy

I session Biology and pre-Clinical Studies – Chairpersons: D.Ngoga, C. Ferrari
09:30 10:00 A. Schwint Radiobiological studies in an experimental model of oral cancer to optimize the therapeutic efficacy of boron neutron capture therapy (BNCT)
10:00 10:20 Nagasaki Kojic Acid-Appended Carborane/Hydroxypropyl-beta-Cyclodextrin Complex for melanoma-targeted BNCT
10:20 10:40 C.Rovelli BNCT preclinical studies for spread lung cancer and limb osteosarcoma treatments
10:40 11:00 M.A. Gadan BNCT for HER2+ breast cancer recurrences: research and development advances in dosimetry and boron carriers
11:00 11:20 A.Monti Hughes Radiotoxicity and Tumor Control Studies of BNCT in the Hamster Cheek Pouch Model of Oral Cancer at the New Configuration of the RA-6 Nuclear Reactor
11:20 11:40 A. Rossini / A. Portu Determination of intracellular boron concentration and characterization of the aminoacid transport system responsible of BPA uptake in human melanomas.
11:40 12:00 Coffee/tea break
12:00 12:20
Kent Riley Award
12:20 Closing
14:30 Visit to LENA and/or CNAO